Drug Induced Hyperkalaemia

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Listed below are some drugs that may cause hyperkalaemia (serum potassium concentration above 5.0 mmol/L)

  • Potassium-sparing diuretics e.g. triamterene, amiloride
  • Aldosterone antagonists/mineralocorticoid receptor antagonists e.g. spironolactone, eplerenone, finerenone
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors) e.g. ramipril, enalapril, lisinopril, captopril, perindopril
  • Angiotensin receptor antagonists (ARBs) e.g. irbesartan, candesartan, losartan, valsartan
  • Aliskiren
  • Beta blockers e.g. propranolol, metoprolol, atenolol
  • Digoxin at toxic level
  • Heparin
  • Low molecular weight heparins e.g. enoxaparin, dalteparin, tinzaparin
  • Trimethoprim
  • Co-trimoxazole
  • Tedizolid
  • Ciclosporin
  • Tacrolimus
  • Voclosporin
  • Pentamidine
  • Potassium supplements or salts
  • Non-steroidal anti-inflammatory drugs (NSAIDs) e.g. indometacin
  • Etoricoxib
  • Celecoxib
  • Epoetin alfa
  • Epoetin beta
  • Ponesimod
  • Rifaximin
  • Itraconazole
  • Propofol
  • Suxamethonium

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