Drug Induced Hypernatraemia

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Listed below are some drugs that may cause hypernatraemia (serum sodium concentration above 145 mmol/L)

  • Diuretics e.g. the osmotic diuretic mannitol, loop diuretics, thiazide diuretics
  • Sodium bicarbonate
  • Sodium chloride
  • Corticosteroids
  • Anabolic steroids
  • Adrenocorticotrophic steroids
  • Androgens
  • Oestrogens
  • Lithium citrate (in overdose)1
  • Lithium carbonate (in overdose)2
  • Tolvaptan
  • Povidone-iodine: application of povidone-iodine to large wounds or severe burns may produce systemic adverse effects such as metabolic acidosis, hypernatraemia and impairment of renal function3
  • Foscarnet4
  • Intravenous antibiotics because of the sodium content (e.g. fosfomycin has a high content of sodium5)

 

References

  1. 1. Rosemont Pharmaceuticals Limited. Li-Liquid 1018 mg/5ml Oral Syrup – Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/6680/smpc [Accessed on 05/10/2023].
  2. Essential Pharma Ltd. Camcolit 400 mg, controlled release Lithium Carbonate – Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/10829/smpc [Accessed on 05/10/2023].
  3. Haleon UK Trading Limited. Savlon Dry – Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/6331/smpc [Accessed on 05/10/2023].
  4. Tillomed Laboratories Ltd. Foscarnet sodium Tillomed 24 mg/ml solution for infusion – Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/13898/smpc [Accessed on 05/10/2023].
  5. Infectopharm. Fomicyt 40 mg/ml powder for solution for infusion – Summary of Product Characteristics. Available at: https://mhraproducts4853.blob.core.windows.net/docs/876a75bc461af7c4642eeea8305d210dc242e95d [Accessed on 05/10/2023].

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