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Home > Pre-Reg Pharmacist > Medications and recreational drugs that can cause insomnia

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Medications that can cause insomnia


Listed below are some medications that can cause insomnia:

  • Monoamine-oxidase inhibitors (MAOIs) e.g. phenelzine, tranylcypromine
  • Selective serotonin re-uptake inhibitors (SSRIs) e.g. fluoxetine, citalopram, sertraline, paroxetine
  • Bupropion
  • Pseudoephedrine
  • Highly lipid soluble beta-blockers such as propranolol, labetalol and metoprolol are more likely to cross the blood-brain barrier and cause insomnia
  • Antiepileptics e.g. lamotrigine, phenytoin
  • Lipophilic statins (simvastatin and atorvastatin) are more likely to cross the blood-brain barrier and cause insomnia
  • Methylphenidate
  • Corticosteroids
  • Levothyroxine (usually due to excessive dosage)
  • Griseofulvin
  • Theophylline
  • Beta2 agonists e.g. salbutamol, salmeterol
  • Oxycodone

 

Recreational drugs that can cause insomnia

Listed below are some recreational drugs that can cause insomnia:

  • Alcohol
  • Caffeine
  • Nicotine
  • Amphetamines
  • Cocaine
  • Methamphetamine
  • Drug withdrawal

 

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