Some Common Substrates, Inhibitors and Inducers of CYP450 Isoenzymes

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CYP3A group (includes 4,5,7)

Substrates Inhibitors Inducers
Amiodarone Cimetidine Carbamazepine
Amlodipine Clarithromycin Efavirenz
Aripiprazole Diltiazem Nevirapine
Atorvastatin Erythromycin Oxcarbazepine
Buspirone Fluconazole Phenobarbital
Ciclosporin Indinavir Phenytoin
Clarithromycin Itraconazole Pioglitazone
Dexamethasone Ketoconazole Rifampicin
Diazepam Nelfinavir St John’s Wort
Diltiazem Ritonavir
Domperidone Saquinavir
Erythromycin Verapamil
Estradiol Grapefruit Juice
Felodipine
Fentanyl
Finasteride
Hydrocortisone
Indinavir
Lercanidipine
Methadone
Nelfinavir
Nifedipine
Progesterone
Ritonavir
Saquinavir
Sildenafil
Simvastatin
Tacrolimus
Testosterone
Verapamil
R-Warfarin

 

CYP2D6

Substrates Inhibitors Inducers
Amitriptyline Amiodarone Rifampicin
Carvedilol Bupropion
Chlorphenamine Celecoxib
Chlorpromazine Cimetidine
Clomipramine Citalopram
Codeine Clomipramine
Dextromethorphan Duloxetine
Donepezil Escitalopram
Duloxetine Fluoxetine
Fluoxetine Levomepromazine
Haloperidol Paroxetine
Imipramine Quinidine
Metoclopramide Sertraline
Metoprolol Terbinafine
Ondansetron
Oxycodone
Paroxetine
Propranolol
Tamoxifen
Timolol
Tramadol
Venlafaxine

 

CYP2C9

Substrates Inhibitors Inducers
Celecoxib Amiodarone Rifampicin
Diazepam Fluconazole Secobarbital
Diclofenac Isoniazid
Fluoxetine
Fluvastatin
Glibenclamide
Glimepiride
Glipizide
Ibuprofen
Irbesartan
Losartan
Meloxicam
Naproxen
Phenytoin
S-Warfarin

 

CYP2C19

Substrates Inhibitors Inducers
Amitriptyline Chloramphenicol Carbamazepine
Citalopram Cimetidine Rifampicin
Clopidogrel Ketoconazole
Diazepam Lansoprazole
Lansoprazole Omeprazole
Omeprazole Oxcarbazepine
Pantoprazole Pantoprazole
Proguanil
Propanolol
R-Warfarin

 

CYP1A2

Substrates Inhibitors Inducers
Amitriptyline Amiodarone Omeprazole
Clomipramine Cimetidine Broccoli
Clozapine Ciprofloxacin Brussels sprouts
Imipramine Fluvoxamine Cigarette Smoking
Theophylline
R-Warfarin
Caffeine

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