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Some Common Substrates, Inhibitors and Inducers of CYP450 Isoenzymes


CYP3A group (includes 4,5,7)

Substrates Inhibitors Inducers
Amiodarone Cimetidine Carbamazepine
Amlodipine Clarithromycin Efavirenz
Aripiprazole Diltiazem Nevirapine
Atorvastatin Erythromycin Oxcarbazepine
Buspirone Fluconazole Phenobarbital
Ciclosporin Indinavir Phenytoin
Clarithromycin Itraconazole Pioglitazone
Dexamethasone Ketoconazole Rifampicin
Diazepam Nelfinavir St John’s Wort
Diltiazem Ritonavir  
Domperidone Saquinavir  
Erythromycin Verapamil  
Estradiol Grapefruit Juice  
Felodipine    
Fentanyl    
Finasteride    
Hydrocortisone    
Indinavir    
Lercanidipine    
Methadone    
Nelfinavir    
Nifedipine    
Progesterone    
Ritonavir    
Saquinavir    
Sildenafil    
Simvastatin    
Tacrolimus    
Testosterone    
Verapamil    
R-Warfarin    

 

CYP2D6

Substrates Inhibitors Inducers
Amitriptyline Amiodarone Rifampicin
Carvedilol Bupropion
Chlorphenamine Celecoxib  
Chlorpromazine Cimetidine  
Clomipramine Citalopram  
Codeine Clomipramine  
Dextromethorphan Duloxetine  
Donepezil Escitalopram  
Duloxetine Fluoxetine  
Fluoxetine Levomepromazine  
Haloperidol Paroxetine  
Imipramine Quinidine  
Metoclopramide Sertraline  
Metoprolol Terbinafine  
Ondansetron    
Oxycodone    
Paroxetine    
Propranolol  
Tamoxifen  
Timolol  
Tramadol  
Venlafaxine  

 

CYP2C9

Substrates Inhibitors Inducers
Celecoxib Amiodarone Rifampicin
Diazepam Fluconazole Secobarbital
Diclofenac Isoniazid  
Fluoxetine    
Fluvastatin  
Glibenclamide  
Glimepiride  
Glipizide  
Ibuprofen  
Irbesartan  
Losartan  
Meloxicam  
Naproxen  
Phenytoin  
S-Warfarin  

 

CYP2C19

Substrates Inhibitors Inducers
Amitriptyline Chloramphenicol Carbamazepine
Citalopram Cimetidine Rifampicin
Clopidogrel Ketoconazole
Diazepam Lansoprazole  
Lansoprazole Omeprazole  
Omeprazole Oxcarbazepine  
Pantoprazole Pantoprazole  
Proguanil  
Propanolol  
R-Warfarin    

 

CYP1A2

Substrates Inhibitors Inducers
Amitriptyline Amiodarone Omeprazole
Clomipramine Cimetidine Broccoli
Clozapine Ciprofloxacin Brussels sprouts
Imipramine Fluvoxamine Cigarette Smoking
Theophylline    
R-Warfarin  
Caffeine

 

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